Purine nucleosides
Apexbio Technology LLC 6-O-Propynyl-2-deoxyguanosine 10mg
6-O-Propynyl-2-deoxyguanosine (CAS 1640051-47-3) is a modified nucleoside featuring an alkyne functional group at the 6-position of deoxyguanosine This structural modification enables its use in bioorthogonal click chemistry reactions facilitating site-specific labeling and conjugation in nucleic acid research The alkynyl group serves as a chemical handle for copper-catalyzed azide-alkyne cycloaddition allowing researchers to attach probes or other functional molecules 6-O-Propynyl-2-deoxyguanosine is utilized for studying DNA structure dynamics and for the development of modified oligonucleotides in biochemical and molecular biology assays
Medchemexpress LLC 6-Thio-2'-Deoxyguanosine | 789-61-7 | 99.7% | 283.31 | 50 MG
6-Thio-2'-Deoxyguanosine is a nucleoside analogue that can be incorporated into de novo-synthesized telomeres by telomerase. It causes rapid cell death for the majority of cancer cell lines tested with IC50s between 0.7-2.9 μM. In A549 lung cancer cell-based mouse xenograft studies, it decreases tumor growth rate and increases telomere dysfunction in tumor cells in vivo.
- Nucleoside analogue
- Incorporated into de novo-synthesized telomeres by telomerase
- Results in rapid cell death for the vast majority of cancer cell lines tested with IC50s of between 0.7-2.9 μM
- Causes a decrease of the tumor growth rate in A549 lung cancer cell-based mouse xenograft studies
- Increases telomere dysfunction in tumor cells in vivo
Genscript Corporation CA15-3 AntibodyA5D8 mAb Mo
CA15-3 (Carcinoma antigen 15-3) is also known as MUC 1 antigen It is a membrane-anchored mucin-type glycoprotein present in malignant cells It is used as tumor marker to monitor breast cancer treatment and disease recurrence
Sigma Aldrich Fine Chemicals Biosciences MCOPPB trihydrochloride hydrate >98% (HPLC) | Purity: >98% (HPLC) | 1028969-49-4 (free base) | 5MG
MCOPPB trihydrochloride hydrate >98% (HPLC) | Purity: >98% (HPLC) | 1028969-49-4 (free base) | 5MG
Medchemexpress LLC N6-Methyladenosine-13C | 2232870-66-3 | 99.9% | 282.26 | 1 MG
N6-Methyladenosine-13C is the 13C labeled isotope of N6-Methyladenosine. It is for research use only and not sold to patients.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC NBI-961 (formerly CMP3a) | 2225902-98-5 | 99.7% | 568.61 g/mol | C28H27F3N6O2S | 10 MG
NBI-961 is a potent NEK2 inhibitor that inhibits proteasomal degradation and induces G2/mitosis arrest and apoptosis in diffuse large B cell lymphoma (DLBCL) cells. It is supplied as a solid, light yellow to yellow research-use-only compound and is available in small amounts for laboratory studies.
- High purity (99.7%).
- Molecular weight 568.61 g/mol.
- Chemical formula C28H27F3N6O2S.
- Soluble in DMSO at 100 mg/mL (requires ultrasonic).
- Powder storage: -20°C for 3 years; 4°C for 2 years.
- Intended for laboratory research use only; not for human or animal use.
Medchemexpress LLC 2'-Deoxyguanosine-13C10,15N5 | 872624-05-0 | 282.13 | 1 MG
2'-Deoxyguanosine-13C10,15N5 is a 13C- and 15N-labeled 2'-Deoxyguanosine for research use only. This compound is used as a tracer or as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process, with deuteration showing potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Apexbio Technology LLC 2'-Deoxyguanosine 961-07-9 5g
2 -Deoxyguanosine (CAS 961-07-9) is a purine deoxyribonucleoside comprising guanine coupled to a deoxyribose moiety As an essential constituent of DNA it serves as a substrate in multiple nucleotide metabolism pathways Its interconversion with 2 -deoxyguanosine 5 -monophosphate is mediated by purine 5 -nucleotidase and deoxyguanosine kinase reflecting its role in nucleic acid turnover In biomedical research 2 -deoxyguanosine is utilized to study DNA synthesis repair mechanisms and enzymatic processes involving nucleoside metabolism Altered deoxyguanosine homeostasis has been implicated in purine nucleoside phosphorylase deficiency underscoring its significance in inherited metabolic disorders
Cambridge Isotope Laboratories 2-Amino-2-deoxyadenosine 5-triphosphate NH4 (ribose-1 2 3 4 5-13C5 99%) (in solution) CP 95% 100 umol
2-Amino-2-deoxyadenosine 5-triphosphate NH4 (ribose-1 2 3 4 5-13C5 99%) (in solution) CP 95% 100 umol
Medchemexpress LLC 2'-deoxyadenosine-5'-monophosphate | 653-63-4 | 99.2% | 331.22 g/mol | C10H14N5O6P | 100 MG
2'-Deoxyadenosine-5'-monophosphate (dAMP) is a deoxynucleotide monophosphate used as a biochemical reagent and reference standard in nucleic acid research and analytical chemistry. Supplied as a white to off-white solid, it is used in enzymatic assays, chromatography, mass spectrometry, and studies of DNA metabolism.
Medchemexpress LLC 2'-Deoxyadenosine monohydrate | 16373-93-6 | 99.89% | 269.26 | 5 G
2'-Deoxyadenosine monohydrate is an adenine nucleoside with multiple biological roles, including inhibiting glucose-stimulated insulin release and islet cyclic AMP (cAMP) accumulation. It activates caspase-3 and promotes apoptosis, and inhibits S-adenosyl-L-homocysteine hydrolase (SAHH) activity. It has shown an anticancer effect on colon cancer and appears as a white to off-white solid.
- Inhibits glucose-stimulated insulin release
- Inhibits glucose-stimulated increases in islet cyclic AMP (cAMP) accumulation
- Activates caspase-3
- Promotes apoptosis
- Inhibits S-adenosyl-L-homocysteine hydrolase (SAHH) activity
- Demonstrated inhibitory effect on the growth of various cells, including anticancer effect on colon cancer
- Appears as a white to off-white solid
Medchemexpress LLC N6-Isopentenyladenosine | 7724-76-7 | 99.4% | 335.36 | 1 ML
N6-Isopentenyladenosine (Riboprine) is an RNA modification found in cytokinins, which are known to regulate plant growth and differentiation. It is also present in a subset of tRNAs, where it enhances the efficiency and accuracy of translation. This compound is an end product of the mevalonate pathway and functions as an autophagy inhibitor, demonstrating interesting anti-melanoma activity.
- RNA modification found in cytokinins
- Regulates plant growth/differentiation
- Improves efficiency and accuracy of translation in tRNAs
- End product of the mevalonate pathway
- Autophagy inhibitor
- Exhibits anti-melanoma activity
Medchemexpress LLC 2'-Deoxyadenosine 5'-triphosphate disodium | 74299-50-6 | 99.9% | 535.15 | 10 MG
2'-Deoxyadenosine 5'-triphosphate disodium is a nucleotide with important biological activities. It serves as a substrate for a variety of polymerases, including DNA polymerases and reverse transcriptases. This compound plays a key role in DNA synthesis and reverse transcription. It is also widely used in in vitro reactions in molecular biology research.
- Serves as a substrate for a variety of polymerases
- Plays a key role in DNA synthesis
- Plays a key role in reverse transcription
- Widely used in in vitro reactions in molecular biology research
Bioworld 2'-Deoxyadenosine Monohydrate, 10 g
A deoxyribonucleoside, may be used by some cells as an energy source under energy stress conditions and to affect cAMP levels. It is used in comparison studies of the functions of adenosine analogues on various biological processes. Specifications:Ultra Pure GradeEM (259nm, phosphate buffer, pH 7.0): >14,500Appearance: White crystalline powderChEBI : Not available.Crystal_Structure : Not available.InChI : Not available.InChIKey : Not available.Melting Point: 187-189 °CRTECS Number: AU7358600
Medchemexpress LLC 2'-Deoxyadenosine-5'-triphosphate-15N5, dilithium | 99.3% | 508.01 | 1 MG
This product is 2'-Deoxyadenosine-5'-triphosphate-15N5, dilithium, a chemical compound with a molecular weight of 508.01. It is supplied as a colorless to light yellow liquid solution and has a purity of 99.3%. This compound is intended for research use only.
- High purity of 99.3%
- Isotopic enrichment of 98.7%
- Available as a colorless to light yellow liquid
- Store at -20°C for up to 2 years
- Molecular formula C10H14Li215N5O12P3